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KMID : 0614519970070000068
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Journal of the Korean Pain Research Society
1997 Volume.7 No. 0 p.68 ~ p.75
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Effect of Protoberberine-related Compounds on the Jaw Opening Reflex Induced by Rat Tooth-pulp Stimulation
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이귀래:Lee Gwi-Lae
한승호:Han Seung-Ho/조영욱:Cho Young-Wuk/김창주:Kim Chang-Ju/민병일:Min Byung-Il
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Abstract
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In forty-two Sprague-Dawley rats, the effects of 5 newly synthesized derivatives of protoberberine on the jaw opening reflex were investigated. Among the 5 compounds, 3 of them were proved to have significant suppressive effects on the tooth pulp-evoked dEMGs in this experiment. These compounds of protoberberine are compound A, compound B and compound C. Chemical structures of these compounds(A, B and C) are closely related to that of α-Allocrytopine, one type of constituent parts of Corydalis tuber. In oriental medicine, Corydalis tuber is well known as a herbal drug with a
strong effect of analgesia. It has been also reported that α-Allocrytopine had a potent muscle relaxant effect in various experiments.
Thus, it is believed that analgesic effects of compound A, B and C came from their similar chemical structure related to that of α-Allocrytopine. As shown in Fig. 8, when administering 2.5 mg/kg of each compound to animals, the amplitudes of dEMGs were maximally suppressed to 62±4% for compound A, 60±3% for compound B and 56±2% for compound C. Thus the rank order of suppressive potency for these three compounds is compound C> compound B> compound A. The difference in the suppression degree among these compounds may be due to different radicals of each compound. Many
drugs such as morphine, fentanyl, pentomorphone, meperidine, clodine and medetomidine were examined for the analgesic effect by using the tooth pulp stimulation technique. But unfortunately, the analgesic potencies of these protoberberine compounds could not be compared with other analgesics except diazepam because of different species, dosage,
etc. The potencies of protoberberine compounds induced inhibition of dEMG were stronger than those of a dose of 2.5 mg/kg of diazepam reported by Iriki et al. Therefore from The result obtained, it can be suggested that protoberberine-related compounds having similar chemical structure related to that of α-Allocrytopine have more potent analgesic effect than diazepam when a same dose was administered.
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KEYWORD
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Protoberberine, Jaw opening reflex, Pain,
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